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Home - Products - Cell Cycle/DNA Damage - ROCK - H-1152 dihydrochloride

H-1152 dihydrochloride

CAS No. 871543-07-6

H-1152 dihydrochloride( —— )

Catalog No. M34747 CAS No. 871543-07-6

H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    H-1152 dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM.
  • Description
    H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    ROCK
  • Recptor
    ROCK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    871543-07-6
  • Formula Weight
    392.34
  • Molecular Formula
    C16H23Cl2N3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 35.71 mg/mL (91.02 mM; Ultrasonic)DMSO : 10 mg/mL (25.49 mM; Ultrasonic (<60°C)
  • SMILES
    Cl.Cl.C[C@H]1CNCCCN1S(=O)(=O)c1cccc2cncc(C)c12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tamura M, et al. Development of specific Rho-kinase inhibitors and their clinical application. Biochim Biophys Acta. 2005 Dec 30;1754(1-2):245-52. Epub 2005 Sep 12.?
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